According to the difference of pressure system in different structural belts of Weining block, the fine study of three pressure profiles is carried out by synthesizing a number of data. On this basis, the wellbore structure of South Ayashi and Winnie structural belts is optimized by using the top-down wellbore structure design method, aiming at providing technical support for excellent and fast drilling in this exploration area. Users of this data should consider the differences in formation pressure systems between various structural zones when applying wellbore structural designs outlined by the data set. The data is derived from detailed rock mechanics experiments, logging, and formation pressure tests, and should be used to tailor drilling parameters and casing programs for specific geological conditions in the Weining block. Utilization should involve a validation process against additional test data to ensure the reliability of the models and their applicability in actual drilling operations. Special attention should be given to the design for ensuring drilling success rates and the avoidance of slim hole drilling completion issues.